Cardiovascular Health Parameters with CVD Incident: Age-Specific Relationship


For one study, researchers sought to investigate age-related changes in measures of cardiovascular health (CVH) for incident cardiovascular disease (CVD). Analyzes were performed using data from the JMDC complaints database from 2005 to 2020 (n = 2,728,427; mean age 44.9 ± 11.0 years; 56.2% male). Participants were divided into 3 age groups: 20-49 years old (n=1,800,161), 50-59 years old (n=644,703) and 60-75 years old (n=283,563 ). Ideal CVH indices included a non-smoker, body mass index less than 25 kg/m2, physical activity at goal, breakfast consumption, blood pressure less than 120/80 mm Hg, blood sugar fasting less than 100 mg/dL and a total cholesterol level less than 200 mg/dL. Approximately 5,988 myocardial infarctions (MI), 53,409 angina pectoris, 26,530 strokes and 52,712 episodes of heart failure (HF) were observed over an average follow-up period of between 1,194 and 917 days. The association between number of non-ideal CVH measurements and CVD incident varied by age group, with 20–49 year olds showing the strongest manifestations of this link. Similarly, the 1-year relative risk reduction for each cardiovascular disease event for an individual with 2 non-ideal CVH parameters that had been reduced to zero also decreased with age. This was the case for both men and women. For example, the relative risk reduction for myocardial infarction was 0.51 in people aged 20-49, 0.48 in those aged 50-59, and 0.40 in those aged 60. at 75 years old. In conclusion, in younger participants, CVH measurements were more closely related to incident CVD, including HF. This indicated the need to focus on improving modifiable risk factors and lifestyle choices in younger populations for the primary prevention of cardiovascular disease.

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